Low Postoperative Platelet Count is Associated with Higher Morbidity after Liver Surgery for Colorectal Metastase

Colorectal cancer is one of the most common malignant diseases [1]. Fifteen to twenty-five percent of patients with colon carcinoma show liver metastases at the time of diagnosis [2]. Furthermore, the same number of patients develops metachronous liver metastases. Development of multimodal strategies combining chemotherapy, targeted therapies (e.g. AB, SMI) and surgery lead to wider curative therapeutic options for liver metastases [3-7]. As a consequence, surgery of liver metastases from colorectal cancer became standard therapy. Nowadays colorectal liver metastases are the leading indication for liver surgery in the western world. One major problem in liver surgery is the postoperative liver failure. It is well known that chemotherapy can lead to liver damage with impaired regenerative capacity [8,9].